Table 1.
Markers of candidate genes used for association studies in sepsis
| Gene | Marker | Association | Reference |
| BPI | Lys-Glu (216) | - | [28] |
| BPI | Noncoding PstI | - | [28] |
| BPI | Synonymous TaqI (545) | - | [28] |
| HSP70-2 | Coding PstI (position?) | - | [38] |
| HSP70-HOM | Met-Thr (493) | - | [38] |
| LBP | Cys-Gly (98) | + (male) | [28] |
| LBP | Leu-Pro (436) | - | [28] |
| LBP | Synonymous HpaII (291) | - | [29] |
| MBL | Exon 1 (codons 52, 54, 57) | + | [25] |
| CD14 | -260 (-159) promoter | - | [31,32] |
| TLR-4 | Asp-Gly (299) | + | [34,35] |
| TLR-4 | Thr-Ile (399) | - | [35] |
| TLR-4 | Rare coding mutations | + | [36] |
| TLR-2 | Arg-Gln (753) | + | [39] |
| TLR-2 | Rare coding mutations | - | [36] |
| FCγRIIa | His-Arg (131) | + | [40] |
| Angiotensin-converting enzyme | Noncoding indela | + | [41] |
| Factor V Leiden | Arg-Gln (506) | + | [42] |
| Plasminogen activator inhibitor-1 | Promoter single base indela | + | [43] |
| Tissue-type plasminogen activator | Noncoding indela | - | [44] |
| IL-1 receptor antagonist | Noncoding microsatellite | + | [27] |
| IL-1β | Synonymous TaqI (297) | - | [27] |
| IL-6 | -174 promoter | - | [45] |
| IL-10 | -1082 promoter | + | [40] |
| TNF-α | -308 promoter | + | [23] |
| TNF-β (LTA) | Noncoding NcoI | + | [27,46] |
BPI, bactericidal/permeability-increasing protein; FcgRIIa, immunoglobulin G Fc receptor II; HSP, heat shock protein; LBP, lipopolysaccharide-binding protein; LTA, lymphotoxin-alpha; MBL, mannose-binding lectin; TLR, Toll-like receptor; TNF, tumor necrosis factor. a Insertion/deletion.