Table 4.

Autophagy-deficient murine models for breast cancer studies^a

Gene	Genotype	Phenotype	Ref.
RB1CC1 or FIP200	Tek-Cre;rb1cc1f/f	Perinatal lethal from severe erythroblastic anemia.	[15]
	rb1cc1f/+;p62+/−	Viable; mammary tumor growth severely impaired in FIP200-null compared with FIP200 and p62 double-knockout mice.	[15]
	rb1cc1−/−	Embryonic lethal at E14.5–15.5.	[15]
	rb1cc1f/f;MMTV-Cre;MMTV-PyMT	Develop palpable mammary tumor with T50 of 85d; >60% decrease in epithelial surface covered by hyperplastic nodules and 2.5-fold reduction in the average mass of the mammary glands compared with that for rb1cc1f/f;MMTV-PyMT mice.	[82]
	rb1cc1f/+;MMTV-Cre;MMTV-PyMT	Develop palpable mammary tumor with T50 of 62d.	[82]
	rb1cc1f/f;MMTV-PyMT	Develop palpable mammary tumor with T50 of 56d.	[82]
Beclin-1	Becn1+/−;MMTV-Wnt1	Display significantly shorter mammary tumor-free survival (4 vs. 7.2 months) and overall survival compared with Becn1+/+;MMTV-Wnt1.	[83]
Tsc1	tsc1f/f;MMTV-PyMT	Viable	[25]

^aModified from Table 2 of [15].