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. 2015 Dec 5;48(1):60–74. doi: 10.1093/abbs/gmv119

Table 4.

Autophagy-deficient murine models for breast cancer studiesa

Gene Genotype Phenotype Ref.
RB1CC1 or FIP200 Tek-Cre;rb1cc1f/f Perinatal lethal from severe erythroblastic anemia. [15]
rb1cc1f/+;p62+/− Viable; mammary tumor growth severely impaired in FIP200-null compared with FIP200 and p62 double-knockout mice. [15]
rb1cc1−/− Embryonic lethal at E14.5–15.5. [15]
rb1cc1f/f;MMTV-Cre;MMTV-PyMT Develop palpable mammary tumor with T50 of 85d; >60% decrease in epithelial surface covered by hyperplastic nodules and 2.5-fold reduction in the average mass of the mammary glands compared with that for rb1cc1f/f;MMTV-PyMT mice. [82]
rb1cc1f/+;MMTV-Cre;MMTV-PyMT Develop palpable mammary tumor with T50 of 62d. [82]
rb1cc1f/f;MMTV-PyMT Develop palpable mammary tumor with T50 of 56d. [82]
Beclin-1 Becn1+/−;MMTV-Wnt1 Display significantly shorter mammary tumor-free survival (4 vs. 7.2 months) and overall survival compared with Becn1+/+;MMTV-Wnt1. [83]
Tsc1 tsc1f/f;MMTV-PyMT Viable [25]

aModified from Table 2 of [15].