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. 2015 Dec 14;212(13):2203–2212. doi: 10.1084/jem.20151093

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© 2015 Arakawa et al.

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Figure 4. — ADAMTSL5 is a psoriasis autoantigen. (A) Representative flow cytometry dot plots for IL-17A– and IFN-γ–producing CD8⁺ T cells as the proportion of total CD8⁺ T cells in a healthy and psoriasis subject. (B and D) Change in the percentage of IL-17A– and IFN-γ–positive CD8⁺ T cells after ADAMTSL5 peptide stimulation of PBMCs from healthy and psoriasis subjects over medium control (B) and differentiated according to HLA-C*06:02 status (D). Data were assessed by multiparametric flow cytometry analysis after CD8 and intracellular cytokine staining and compared by two-tailed Mann-Whitney U test. Each dot represents one subject; *, P < 0.05; ***, P < 0.005. (C and E) Change in IL-17A and IFN-γ secretion of PBMCs stimulated with ADAMTSL5 or control peptide over medium control as evaluated by ELISA (C) and differentiated according to HLA-C*06:02 status (E). Dashed lines indicate the positive threshold. *, P < 0.05; ***, P < 0.005; two tailed Fisher’s exact test.