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. 2015 Dec 14;212(13):2203–2212. doi: 10.1084/jem.20151093

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© 2015 Arakawa et al.

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Figure 5. — ADAMTSL5 is selectively expressed by melanocytes in epidermis. (A) ADAMTSL5 mRNA expression in healthy skin (n = 2), primary melanocytes (n = 3), and WM278 cells was assessed by qPCR in triplicates and normalized to PBGD. Data are given as mean ± SD. (B) Immunostaining of ADAMTSL5 (green; overlay with red: yellow) and MART-1 (red) in healthy skin (n = 3) and psoriasis (n = 3). Dashed lines indicate basal membrane, and arrowheads indicate ADAMTSL5 expression by melanocytes. (C) Representative image of a CD8⁺ T cell (blue) contacting a melanocyte (red) expressing ADAMTSL5 (green; overlay with red: yellow) in psoriasis (n = 2). Bars: (B, left) 20 µm; (B [right] and C) 10 µm.