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. Author manuscript; available in PMC: 2016 Sep 23.
Published in final edited form as: J Am Chem Soc. 2015 Sep 15;137(37):12100–12109. doi: 10.1021/jacs.5b07772

Figure 4.

Figure 4

Comparison of holo- (a, in pink) and loaded-ArCP (c, in blue) in complex with an adenylation domain in AT conformation (in white). The original structure of EntB-ArCP (brown) in complex with EntE is shown in b) (2ROG). In b), EntB-ArCP sidechains colored in red highlight interactions between A(N) and α2, those in blue show interactions between A(C) and ArCP, and those in green denote interactions between A(C) and loop1. The same color scheme was used for side-chains of EntE that are displayed in a–c). d) Detail showcasing changes in the conformation of loop1. The orientation in d is obtained by rotation of 30° around the Y vertical axis.