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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Toxicol Appl Pharmacol. 2015 Jun 3;287(2):149–160. doi: 10.1016/j.taap.2015.05.019

Figure 7.

Figure 7

Relative mRNA expression in selected Akr 1c metabolizing enzymes measured 2, 4, and 8 h post initiation with 0.125 mL toluene or 400 nmol DBC applied to the shaved dorsal surface of Cyp 1b1+/+ (wt), Cyp 1b1+/− (het), and Cyp 1b1−/− (null) mice. qPCR using the ΔΔCt method of expression in treated animals relative to toluene control are shown as mean ± SE of individual 2−(ΔΔCt) values. ψ indicates significant difference between control and treated based on Mann Whitney two tailed test, φ indicates significant difference between genotypes and α indicates significance between time points using Kruskal-Wallis ANOVA with Dunn’s post-test; all p values <0.05 .