Figure 1.

VEGF receptors and the structure of aflibercept.

Notes: VEGF receptor-1 (A) and VEGF receptor-2 (B) are related receptors that have seven extracellular Ig domains and an intracellular tyrosine kinase domain. VEGF trap (C) contains the Ig domain 2 of VEGF receptor-1 fused to the Ig domain 3 of VEGF receptor-2, which is in turn fused to the IgG1 Fc. Image obtained from VEGF Trap-Eye (aflibercept ophthalmic solution) Briefing Document.¹³¹

Abbreviation: VEGF, vascular endothelial growth factor; Ig, immunoglobulin; IgG1, immunoglobulin G1; Fc, fragment crystallizable.