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. 2015 Dec 16;11:3075–3083. doi: 10.2147/NDT.S92497

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© 2015 Huang et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Significant differences in spontaneous brain activity between the ON group and HCs.

Notes: The different brain regions are seen in the bilateral cerebellum posterior lobe, right cerebellum anterior lobe, right putamen, right inferior frontal gyrus, right insula, left medial frontal gyrus, left superior temporal gyrus, right supramarginal gyrus, bilateral anterior cingulate/medial frontal gyrus, bilateral precuneus, right inferior parietal lobule, left cerebellum posterior lobe, right inferior temporal gyrus, left parahippocampal gyrus, right inferior temporal/fusiform gyrus, left fusiform gyrus, left calcarine fissure, left inferior parietal lobule, and left cuneus. The red areas denote higher ALFF brain regions, and the blue areas denote lower ALFF brain regions (P<0.05 for multiple comparisons using Gaussian random-field theory (z>2.3, cluster-wise P<0.05 corrected).

Abbreviations: ON, optic neuritis; HCs, healthy controls; ALFF, amplitude of low-frequency fluctuation; L, left; R, right.