Table 2.

Brain regions with significant differences in ALFF between the ON and HC groups

ON group and HCs				MNI coordinates
Brain areas	BA	t-score of peak voxels	Voxels	x	y	z
ON < HCs
Right cerebellum posterior lobe	–	−2.686	21	33	−66	−21
Right cerebellum anterior lobe	–	−3.890	35	15	−48	−21
Right putamen	–	−3.657	35	21	9	−3
Right inferior frontal gyrus	47	−4.642	33	51	42	−3
Right insula	48	−3.048	33	33	12	3
Left medial frontal gyrus	10	−4.711	146	−6	60	18
Left superior temporal gyrus	39	−3.387	23	−60	−57	24
Right supramarginal gyrus	40	−3.656	29	54	−48	24
Bilateral anterior cingulate/medial frontal gyrus	32, 10, 6, 8	−5.489	341	−3	36	30
Bilateral precuneus	7, 31	−3.728	91	12	−51	33
Right supramarginal gyrus	40	−3.724	48	63	−30	39
Right inferior parietal lobule	40, 42, 48	−3.254	32	48	−57	51
ON > HCs
Left cerebellum posterior lobe	–	4.516	116	−48	−69	−33
Right cerebellum posterior lobe	–	4.101	39	24	−78	−54
Right inferior temporal gyrus	20	3.155	28	42	−6	−45
Left parahippocampal gyrus	20, 36	3.803	101	−36	−24	−21
Right inferior temporal/fusiform gyrus	20, 37	3.387	79	45	−21	−24
Left fusiform gyrus	37	4.018	20	−30	−45	−18
Left parahippocampal gyrus	20	3.677	36	−30	−54	−6
Left calcarine fissure	19	5.999	41	−24	−75	6
Left inferior parietal lobule	42, 48	4.219	31	−51	−36	21
Left cuneus	19	3.491	38	−15	−90	33

Notes: Statistical threshold set at voxels with P<0.05 for multiple comparisons using Gaussian random-field theory (z>2.3, cluster-wise P<0.05 corrected).

Abbreviations: ALFF, amplitude of low-frequency fluctuation; ON, optic neuritis; HC, healthy control; MNI, Montreal Neurological Institute; BA, Brodmann area; –, not applicable.