Table 1.
Differences between male and female patients as well as early-onset and late-onset patients with AD
| Characteristics | Total AD (n=117) |
Male (n=57) |
Female (n=60) |
P-value | EOAD (n=62) (male, 28) |
LOAD (n=55) (male, 29) |
P-value |
|---|---|---|---|---|---|---|---|
| Age at onset (years) (n=107) | 63.59 (9.1) | 65.0 (8.5) | 62.3 (9.5) | 0.16 | 57.1 (5.2) | 72.2 (5.1) | irrel |
| Age at lumbar puncture (years) (n=117) | 66.9 (9.0) | 68.7 (8.1) | 65.4 (9.5) | 0.057 | 60.3 (6.5) | 74.4 (4.4) | irrel |
| Duration of the disease in years (n=107) | 2.5 (2.3) | 2.8 (2.8) | 2.2 (1.6) | 0.19 | 2.7 (2.6) | 2.2 (1.8) | 0.21 |
| Years of education (n=109) | 12.2 (3.9) | 12.4 (4.0) | 12.0 (3.8) | 0.55 | 12.3 (4.2) | 12.1 (3.5) | 0.77 |
| MMSE (n=117) | 22.3 (4.3) | 23.2 (3.7) | 21.5 (4.7) | 0.03* | 21.9 (4.7) | 22.8 (3.9) | 0.31 |
| CSF Aβ1-42 level ‡(pg/mL) (n=117) | 541 (186) | 515 (153) | 566 (212) | 0.14 | 533 (190) | 551 (184) | 0.61 |
| CSF t-tau level* (pg/mL) (n=116) | 635 (362) | 577 (373) | 683 (347) | 0.11 | 657 (354) | 609 (372) | 0.48 |
| Positive family history (%) (n=107) | 34.9 | 35.5 | 34.5 | 0.93 | 39.3 | 28.9 | 0.26 |
| ApoE genotype (n=117) | 0.61 | 0.87 | |||||
| • ε2/ε2 | 0 | 0 | 0 | 0 | 0 | ||
| • ε2/ε3 | 6 | 3 | 3 | 3 | 3 | ||
| • ε2/ε4 | 4 | 3 | 1 | 1 | 3 | ||
| • ε3/ε3 | 36 | 15 | 21 | 20 | 16 | ||
| • ε3/ε4 | 49 | 26 | 23 | 26 | 23 | ||
| • ε4/ε4 | 22 | 9 | 13 | 12 | 10 |
Notes:
‡
Normal values for cognitively healthy persons: Aβ1-42 level >643 pg/mL; t-tau level <252 pg/mL. Mean and standard deviation in parentheses (SD). A comparison between male/female and EOAD/LOAD groups was performed.
*
P<0.05.
Abbreviations: AD, Alzheimer’s disease; Aβ1-42, amyloid-β 1-42; ApoE, apolipoprotein E; CSF, cerebrospinal fluid; EOAD, early-onset Alzheimer’s disease; irrel, irrelevant; LOAD, late-onset Alzheimer’s disease; MMSE, Mini Mental State Examination; t-tau, total-tau.