Table 2.
Differences of CSF biomarker levels between ApoE ε4 noncarriers, heterozygous, and homozygous ε4 carriers in the whole patient sample (all patients) and in the different age groups (EOAD and LOAD)
| CSF biomarkers | ε4 noncarriers | One ε4 allele carriers | ε4/ε4 carriers | P-value (adjusted) |
|---|---|---|---|---|
| CSF Aβ1-42 level (pg/mL) | ||||
| All patients | (n=41) | (n=54) | (n=22) | 0.002* |
| 581 (228) | 559 (161) | 422 (93) | ||
| EOAD | (n=22) | (n=28) | (n=12) | 0.176 |
| 583 (210) | 533 (192) | 441 (103) | ||
| LOAD | (n=19) | (n=26) | (n=10) | 0.003* |
| 578 (253) | 588 (115) | 400 (77) | ||
| CSF t-tau level (pg/mL) | ||||
| All patients | (n=41) | (n=54) | (n=22) | 0.63 |
| 591 (342) | 647 (375) | 667 (377) | ||
| EOAD | (n=22) | (n=28) | (n=12) | 0.69 |
| 612 (349) | 704 (394) | 634 (278) | ||
| LOAD | (n=19) | (n=26) | (n=10) | 0.68 |
| 568 (342) | 602 (355) | 706 (483) | ||
Notes: Mean and standard deviation in parentheses (SD); P-values are adjusted for sex and MMSE score;
*
Significant differences between ε4 noncarriers and ε4/ε4 carriers and between heterozygous and homozygous ε4 carriers: P=0.001.
Abbreviations: Aβ1-42, amyloid-β 1-42; CSF, cerebrospinal fluid; EOAD, early-onset Alzheimer’s disease; LOAD, late-onset Alzheimer’s disease; MMSE, Mini Mental State Examination; t-tau, total-tau; ApoE ε4, ε4 allele of the apolipoprotein E.