Table 2.
Association between HCV Genotypes and Risk of Incident Cirrhosis (column 2) and Hepatocellular Cancer (column 3) – Results of Multivariable Cox Regression Analyses
| Characteristics | Adjusted Hazard Ratio (95% confidence Interval) | |
|---|---|---|
| Incident Cirrhosis | Incident HCC | |
| HCV genotype | ||
| 1 | 1.0 | 1.0 |
| 2 | 0.68 (0.64, 0.73) | 0.55 (0.47, 0.63) |
| 3 | 1.30 (1.22, 1.39) | 1.80 (1.60, 2.03) |
| 4 | 0.94 (0.78, 1.14) | 0.99 (0.68, 1.45) |
| Demographics | ||
| Age | 1.03 (1.02, 1.03) | 1.07 (1.06, 1.08) |
| Gender | ||
| Female | 1.0 | 1.0 |
| Male | 1.16 (1.03, 1.32) | 2.78 (1.77, 4.38) |
| Race | ||
| White | 1.0 | 1.0 |
| African American | 0.58 (0.56, 0.61) | 0.73 (0.66, 0.79) |
| Hispanic | 1.28 (1.19, 1.37) | 1.53 (1.34, 1.74) |
| Others | 0.89 (0.79, 1.05) | 0.86 (0.63, 1.19) |
| Missing | 0.79 (0.73, 0.86) | 0.82 (0.69, 0.98) |
| Period of Service | ||
| World War I/II | 1.0 | 1.0 |
| Vietnam | 1.29 (1.16, 1.44) | 1.38 (1.15, 1.66) |
| Post-Vietnam | 1.12 (0.98, 1.29) | 0.95 (0.74, 1.22) |
| Clinical factors | ||
| Yes of HCV diagnosis | ||
| 2000–2002 | 1.0 | 1.0 |
| 2003–2005 | 1.09 (1.04, 1.14) | 1.24 (1.14, 1.36) |
| 2005–2009 | 1.36 (1.27, 1.46) | 1.94 (1.68, 2.24) |
| Diabetes | ||
| No | 1.0 | 1.0 |
| Yes | 1.34 (1.26, 1.42) | 1.34 (1.21, 1.49) |
| Alcohol use | ||
| No | 1.0 | 1.0 |
| Yes | 1.16 (1.12, 1.20) | 1.21 (1.12, 1.30) |
| HIV co-infection | ||
| No | 1.0 | 1.0 |
| Yes | 1.09 (1.00, 1.20) | 0.91 (0.75, 1.13) |
| Body mass index | ||
| <18.5 | 1.0 | 1.0 |
| 18.5 – 24 | 1.05 (0.86, 1.27) | 1.18 (0.82, 1.72) |
| 25 – 29 | 1.18 (0.97, 1.43) | 1.14 (0.78, 1.64) |
| ≥30 | 1.42 (1.18, 1.73) | 1.21 (0.83, 1.75) |
| Antiviral treatment | ||
| No treatment | 1.0 | 1.0 |
| Sustained response | 0.74 (0.68, 0.81) | 0.36 (0.29, 0.46) |
| No response | 1.99 (1.89, 2.10) | 1.30 (1.16, 1.46) |