Table 3.

Association between HCV Genotypes (1–4) and Risk of Incident Hepatocellular Cancer in Subgroup Analyses – Table presents adjusted hazard ratios from Cox regression models in various defined subgroups

Defined subgroup	* Adjusted hazard ratio (95% confidence interval)
Patients with cirrhosis (n=21,716)
1	1.0
2	0.62 (0.50, 0.77)
3	1.44 (1.23, 1.68)
4	0.96 (0.96, 1.22)
Younger patients (50 year and younger) (n=55,424)
1	1.0
2	0.34 (0.24, 0.46)
3	1.86 (1.56, 2.22)
4	1.21 (0.71, 2.05)
Older patients (older than 50 year) (n=54,898)
1	1.0
2	0.65 (0.55, 0.76)
3	1.79 (1.53, 2.11)
4	0.81 (0.47, 1.40)
White (n=57,970)
1	1.0
2	0.59 (0.49, 0.70)
3	1.93 (1.68, 2.21)
4	1.66 (1.07, 2.56)
African American (n=36,693)
1	1.0
2	0.44 (0.26, 0.73)
3	1.23 (0.67, 2.37)
4	0.40 (0.05, 1.00)
Patients without diabetes (n=98,143)
1	1.0
2	0.55 (0.47, 0.64)
3	1.87 (1.65, 2.12)
4	1.13 (0.76, 1.67)
Patients with diabetes (n=12,179)
1	1.0
2	0.54 (0.36, 0.80)
3	1.30 (1.88, 1.90)
4	0.38 (0.09, 1.53)

^*Adjusted for age at the time of HCV diagnosis, year of birth, period of service (World War I/II, Vietnam era, post-Vietnam era), race, gender, diabetes, alcohol use, obesity, HIV infection, and receipt and success of antiviral treatment