. Author manuscript; available in PMC: 2016 May 1.

Published in final edited form as: J Bone Miner Res. 2015 May;30(5):837–854. doi: 10.1002/jbmr.2421

Table 1.

Histomorphometric Measures of Long Bones in 5-Month-Old WT and Netrin-1^−/− Mice

	Wild type	Netrin-1^−/−
Bone volume (BV, mm³)	72.61 ± 2.09	85.67 ± 1.57^***
Trabecular volume (TV, %)	75.70 ± 2.05	85.60 ± 1.63^***
BV/TV	0.87 ± 0.04	0.94 ± 0.05^*
Trabecular number (Tb.N)	0.28 ± 0.04	0.63 ± 0.02^***
Trabecular separation (Tb.Sp, µm)	327.47 ± 8.30	341.15 ± 7.06^*
Osteoid number	6.53 ± 0.91	9.51 ± 1.82^*
Osteoid surface (OS/BS)	0.32 ± 0.10	0.42 ± 0.07^*
Osteoblast number (Ob.N)	22.4 ± 4.65	29.5 ± 2.10^*
Osteoblast surface (Ob.N/BS)	0.35 ± 0.09	0.39 ± 0.02^*
Osteoclast number (Oc.N)	28.75 ± 4.10	19.00 ± 3.51^*
Osteoclast surface (Oc.S)	0.51± 0.16	0.36 ± 0.02^*

Histomorphometric measures on long bones were calculated using the Bioquant Osteo software (mean ± SEM, n = 4 per group).

^***

p < 0.001,

p < 0.05 versus wild type (Student’s t test).