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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Biochim Biophys Acta. 2015 Oct 19;1860(1 0 0):67–78. doi: 10.1016/j.bbagen.2015.10.015

Fig. 12.

Fig. 12

Reorientation of the gating residues of tunnel 2 f and tunnel S, F105 and M460, in T. brucei CYP51 during egress of the ligand, MCP. The side chain orientations of F105 and M460 are shown before (A) and during (B) ligand exit via tunnel 2 f and before (C) and during (D) ligand exit via tunnel S. The secondary structure is shown in yellow and the heme in cyan. Different views of the corresponding snapshots with a surface representation of the protein are shown in Fig. S4A–D.