TABLE 1.

Comparison of the lipid measures reported in (22) and model simulations of the LMK model

	RVX-208 (150 mg Dose)
	Reported Data	Model Simulation
Upregulation of ApoA-I synthesis (%)	NA	6.8
Change in HDL-C (%)	8.3 (−1.9 to 17.9)	8.3 (7.6–9.1)
Change in ApoA-I (%)	5.6 (−1.1 to 14.3)	5.9 (5.4–6.6)
Change in HDL particle concentration (%)	5.1 (−4.8 to 16.5)	4.8 (4.3–5.2)
Change in HDL particle size (%)	1.1 (−1.1 to 2.4)	0.7 (0.6–0.7)
Change in LDL-C (%)	1.0 (−14.2 to 10.1)	8.4 (7.8–9.3)
Change in RCT rate (%)		8.5 (7.9–9.4)

Clinical data are given with their median and interquartile range; simulation results are given with mean and 95% CI of mean .