TABLE 5.

Comparison of free plasma eicosanoid metabolites by obstructive CAD status

Analyte (pg/ml)	No Obstructive CAD (n = 90)	Obstructive CAD (n = 72)	Pa	FDR q
AA-CYP epoxides
14,15-EET	312 (164)	286 (117)	0.002	0.021
11,12-EET	181 (99)	152 (85)	<0.001	0.019
8,9-EET	211 (100)	189 (87)	0.002	0.021
AA-sEH diols
14,15-DHET	981 (490)	845 (442)	0.006	0.031
11,12-DHET	642 (367)	563 (257)	0.009	0.034
8,9-DHET	252 (194)	217 (110)	0.019	0.059
5,6-DHET	268 (177)	229 (122)	0.008	0.034
AA-CYP hydroxyls
19-HETE	694 (408)	588 (267)	0.006	0.031
20-HETE	1,270 (827)	1,087 (664)	0.076	0.134
AA-LOX metabolites
15-HETE	1,021 (620)	847 (382)	0.010	0.036
11-HETE	6,361 (3,944)	5,361 (3,222)	0.024	0.066
12-HETE	70 (42)	53 (38)	0.047	0.101
8-HETE	13,028 (8,100)	12,094 (5,639)	0.068	0.134
5-HETE	2,426 (1,707)	2,068 (1,478)	0.076	0.134
LA-CYP epoxides
12,13-EpOME	1,786 (918)	1,652 (1,127)	0.083	0.135
9,10-EpOME	4,350 (2,562)	3,817 (2,921)	0.046	0.101
LA-sEH diols
12,13-DHOME	2,911 (1,916)	2,466 (1,929)	0.109	0.170
9,10-DHOME	1,961 (1,162)	1,432 (1,158)	0.046	0.101
LA-LOX metabolites
13-HODE	21,839 (10,222)	19,661 (12,561)	0.141	0.208
9-HODE	15,489 (8,711)	14,728 (10,611)	0.180	0.230
9,12,13-TriHOME	718 (742)	668 (829)	0.240	0.292
9,10,13-TriHOME	9,478 (742)	8,406 (13,552)	0.304	0.340
EPA/DHA-epoxides/diols
19,20-EpDPE	1,666 (1,477)	1,641 (888)	0.253	0.295
19,20-DiHDPA	1,206 (741)	1,188 (596)	0.581	0.603
17,18-DHET	2,806 (2,184)	2,671 (1,740)	0.181	0.230
AA-COX metabolites
8-iso-PGF2α	29 (11)	28 (12)	0.157	0.220
6-keto-PGF1α	51 (20)	50 (21)	0.748	0.748
PGF2α	229 (539)	326 (788)	0.379	0.409

DiHDPA,dihydroxydocosapentaenoic acid; EpDPE, epoxydocosapentaenoic acid; PGF, prostaglandin F; TriHOME, trihydroxyoctadecenoic acid. Data presented as median (interquartile range).

^aStudent’s t-test was performed on log-transformed data followed by FDR calculations to account for multiple testing.