Fig. 4.

Hematopoietic ABCA1 deletion increased macrophage accumulation and inflammation and worsened insulin resistance in the liver. BMT-WT and BMT-ABCA1^−/− mice were fed the HFHSC diet for 22 weeks. A: Liver sections were stained with the macrophage-specific antibody, F4/80. B: Quantification of macrophage F4/80 staining is shown. C: Expression of inflammatory genes in the liver. D: Liver Akt phosphorylation after insulin stimulation in vivo in mice. *P < 0.05 versus BMT-WT; n = 5–10 per group.