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. 2015 Dec 23;10(12):e0145508. doi: 10.1371/journal.pone.0145508

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© 2015 Qu et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 7 — (A) W-7 (100 μM) strongly suppressed the Kir currents. The channel inhibition took place rapidly within 1 min after the exposure, lasted for a short period (1–2 min), and then became desensitized. (B) Quantitatively, W-7 inhibited the currents by 77.2 ± 0.1% (n = 9). The channel inhibition was recovered by 94.84% in 5.7 ± 2.1 min after application of W-7 (n = 9). (C) CaMKII inhibitor KN-62 (10 μM) suppressed the Kir currents after PAECs were exposed for 1.5 min and the inhibition was not recovered. (D) Quantitatively, KN-62 inhibited the currents by 71 ± 0.1% (n = 5). ^* P<0.05 versus control.