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. 2015 Dec 23;10(12):e0145666. doi: 10.1371/journal.pone.0145666

Fig 4. BR-4628 reduces kidney gene expression of pro-fibrotic molecules in anti-GBM glomerulonephritis.

Fig 4

RT-PCR analysis showed that in comparison to normal control (NC) mice, there was a marked increase in the kidney mRNA levels of (A) collagen 1 (α1 chain), (B) fibronectin and (C) TGF-β1 at day 15 of glomerulonephritis in mice receiving no treatment (No Tx), which was similar to mice receiving vehicle. Treatment with BR-4628 reduced the kidney mRNA level of each of these profibrotic molecules. Data = mean ± SEM; n = 8. **p<0.01, ***p<0.001, NS = not significant.