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. 2015 Dec 23;10(12):e0145441. doi: 10.1371/journal.pone.0145441

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© 2015 Wang et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 4 — A, B) Western blots showed increase in abnormal hyperphosphorylation of tau in AAV1-I₁ ^PP2A rats. Quantitative analysis of the blots of hyperphosphorylated tau normalized with total tau showed significant increase in tau hyperphosphorylation at several sites studied and memantine was found to reverse this change. *P<0.05, **P<0.01 AAV1-I₁ ^PP2A vs. AAV1-GFP rats; ^ΔP<0.05, ^ΔΔP<0.01 AAV1-I₁ ^PP2A-memantine vs. AAV1-I₁ ^PP2A-vehicle.