Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Dec 23;10(12):e0145441. doi: 10.1371/journal.pone.0145441

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2015 Wang et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

Fig 6 — A,B) As compared with AAV1-GFP rats, AAV1-I₁ ^PP2A rats showed a marked decrease in the expression of somatodendritic marker MAP2 and synaptic markers synapsin and synaptophysin in the hippocampus. Memantine treatment restored dendritic and synaptic loss. B) Western blots showed that β III tubulin staining was significantly decreased in the hippocampus of AAV1-I₁ ^PP2A rats as compared with AAV1-GFP control animals. Memantine restored the decrease to physiological level. C)Fluoro Jade staining showed a selective neurodegeneration in the AAV1-I₁ ^PP2A rat dentate gyrus of the hippocampus. Memantine prevented the neurodegeneration in the AAV1-I₁ ^PP2A rats. 3–4 rats were employed in each experiment. *P<0.05, **P<0.01 AAV1-I₁ ^PP2A vs. AAV1-GFP rats; ^ΔP<0.05, ^ΔΔP<0.01 AAV1-I₁ ^PP2A-memantine vs. AAV1-I₁ ^PP2A-vehicle. Scale bar in A and D, 100 μm.