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. 2015 Dec 23;10(12):e0145702. doi: 10.1371/journal.pone.0145702

Table 3. Representative genes in several important Gene Ontology categories.

GO categories Gene Symbol Description RPKM (Active) RPKM (Torpid) Gfold value
Carbohydrate metabolic process (GO: 0005975)
GCK glucokinase (hexokinase 4) 4.819 0.702 -1.456
HK1 hexokinase 1 22.893 6.899 -1.407
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 12.190 3.827 -1.241
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 20.800 7.201 -1.366
PYGM phosphorylase, glycogen, muscle 5.059 1.689 -0.751
PFKP phosphofructokinase, platelet 10.738 4.764 -0.734
G6PC glucose-6-phosphatase, catalytic subunit 14.265 38.304 1.370
GYS2 glycogen synthase 2 2.708 6.473 0.937
GYS1 glycogen synthase 1 1.230 3.697 0.250
Lipid metabolic process (GO: 0006629)
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 11.313 3.715 -1.235
ACSF3 acyl-CoA synthetase family member 3 5.412 1.670 -1.088
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6 0.310 5.511 2.228
ACOT12 acyl-CoA thioesterase 12 5.082 11.520 0.683
ACOX1 acyl-CoA oxidase 1, palmitoyl 1.004 2.556 0.659
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase 1.121 2.605 0.327
Lipid binding (GO: 0008289)
FABP5 fatty acid binding protein 5 9.236 39.802 1.539
FABP4 fatty acid binding protein 4, adipocyte 14.276 49.609 1.348
FABP1 fatty acid binding protein 1, liver 171.968 367.217 0.882
FABPH Fatty acid-binding protein, heart 4.347 12.601 0.774
FFAR2 free fatty acid receptor 2 0.548 2.964 0.553
Cellular amino acid and derivative metabolic process (GO: 0006519)
PHGDH phosphoglycerate dehydrogenase 12.837 1.375 -2.447
ASS1 argininosuccinate synthase 1 18.177 4.186 -1.843
CBS cystathionine-beta-synthase 8.222 2.704 -1.067
PSAT1 phosphoserine aminotransferase 1 32.104 15.772 -0.727
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 2.927 9.865 1.308
APOA2 apolipoprotein A-II 132.423 331.358 1.295
PAH phenylalanine hydroxylase 2.677 6.407 0.717
GPT2 glutamic pyruvate transaminase 2 3.448 7.536 0.698
HPD 4-hydroxyphenylpyruvate dioxygenase 2.591 5.434 0.385
Response to stress (GO: 0006950)
HSPH1 heat shock 105kDa/110kDa protein 1 0.108 3.053 2.779
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4 0.139 1.816 1.582
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 14.705 38.995 1.145
HSPA4L heat shock 70kDa protein 4-like 5.917 12.814 0.978
HSPA8 heat shock 70kDa protein 8 30.299 66.233 0.917
HSPB7 heat shock 27kDa protein family, member 7 0.520 3.922 0.751
HSPB1 heat shock 27kDa protein 1 1.301 4.598 0.649
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 3.370 7.077 0.611
OXSR1 oxidative-stress responsive 1 0.739 2.089 0.098

Genes with positive/negative gfold values were up/down regulated during torpor.