Table 3. Representative genes in several important Gene Ontology categories.
GO categories | Gene Symbol | Description | RPKM (Active) | RPKM (Torpid) | Gfold value |
---|---|---|---|---|---|
Carbohydrate metabolic process (GO: 0005975) | |||||
GCK | glucokinase (hexokinase 4) | 4.819 | 0.702 | -1.456 | |
HK1 | hexokinase 1 | 22.893 | 6.899 | -1.407 | |
PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 12.190 | 3.827 | -1.241 | |
PFKFB1 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 | 20.800 | 7.201 | -1.366 | |
PYGM | phosphorylase, glycogen, muscle | 5.059 | 1.689 | -0.751 | |
PFKP | phosphofructokinase, platelet | 10.738 | 4.764 | -0.734 | |
G6PC | glucose-6-phosphatase, catalytic subunit | 14.265 | 38.304 | 1.370 | |
GYS2 | glycogen synthase 2 | 2.708 | 6.473 | 0.937 | |
GYS1 | glycogen synthase 1 | 1.230 | 3.697 | 0.250 | |
Lipid metabolic process (GO: 0006629) | |||||
AGPAT2 | 1-acylglycerol-3-phosphate O-acyltransferase 2 | 11.313 | 3.715 | -1.235 | |
ACSF3 | acyl-CoA synthetase family member 3 | 5.412 | 1.670 | -1.088 | |
SLC27A6 | solute carrier family 27 (fatty acid transporter), member 6 | 0.310 | 5.511 | 2.228 | |
ACOT12 | acyl-CoA thioesterase 12 | 5.082 | 11.520 | 0.683 | |
ACOX1 | acyl-CoA oxidase 1, palmitoyl | 1.004 | 2.556 | 0.659 | |
EHHADH | enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase | 1.121 | 2.605 | 0.327 | |
Lipid binding (GO: 0008289) | |||||
FABP5 | fatty acid binding protein 5 | 9.236 | 39.802 | 1.539 | |
FABP4 | fatty acid binding protein 4, adipocyte | 14.276 | 49.609 | 1.348 | |
FABP1 | fatty acid binding protein 1, liver | 171.968 | 367.217 | 0.882 | |
FABPH | Fatty acid-binding protein, heart | 4.347 | 12.601 | 0.774 | |
FFAR2 | free fatty acid receptor 2 | 0.548 | 2.964 | 0.553 | |
Cellular amino acid and derivative metabolic process (GO: 0006519) | |||||
PHGDH | phosphoglycerate dehydrogenase | 12.837 | 1.375 | -2.447 | |
ASS1 | argininosuccinate synthase 1 | 18.177 | 4.186 | -1.843 | |
CBS | cystathionine-beta-synthase | 8.222 | 2.704 | -1.067 | |
PSAT1 | phosphoserine aminotransferase 1 | 32.104 | 15.772 | -0.727 | |
SLC7A6 | solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 | 2.927 | 9.865 | 1.308 | |
APOA2 | apolipoprotein A-II | 132.423 | 331.358 | 1.295 | |
PAH | phenylalanine hydroxylase | 2.677 | 6.407 | 0.717 | |
GPT2 | glutamic pyruvate transaminase 2 | 3.448 | 7.536 | 0.698 | |
HPD | 4-hydroxyphenylpyruvate dioxygenase | 2.591 | 5.434 | 0.385 | |
Response to stress (GO: 0006950) | |||||
HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.108 | 3.053 | 2.779 | |
DNAJB4 | DnaJ (Hsp40) homolog, subfamily B, member 4 | 0.139 | 1.816 | 1.582 | |
HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 14.705 | 38.995 | 1.145 | |
HSPA4L | heat shock 70kDa protein 4-like | 5.917 | 12.814 | 0.978 | |
HSPA8 | heat shock 70kDa protein 8 | 30.299 | 66.233 | 0.917 | |
HSPB7 | heat shock 27kDa protein family, member 7 | 0.520 | 3.922 | 0.751 | |
HSPB1 | heat shock 27kDa protein 1 | 1.301 | 4.598 | 0.649 | |
HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 3.370 | 7.077 | 0.611 | |
OXSR1 | oxidative-stress responsive 1 | 0.739 | 2.089 | 0.098 |
Genes with positive/negative gfold values were up/down regulated during torpor.