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. 2015 Dec 23;10(12):e0145556. doi: 10.1371/journal.pone.0145556

Fig 4. Effects of berberine (BER) on opioid receptor expression in the mouse ileum and colon.

Fig 4

A: Berberine i.p. (1, 2 and 5 mg/kg) increased MOR mRNA expression in the mouse ileum in a dose-dependent manner, and berberine i.p. (2 and 5 mg/kg) increased MOR expression in the mouse colon. *P<0.05,**P<0.01 and ***P<0.001, vs. ileum control; # P<0.05, ### P<0.001, vs. colon control. B: Berberine i.p. (1, 2 and 5 mg/kg) increased DOR mRNA expression in the mouse ileum in a dose-dependent manner, and berberine i.p. (5 mg/kg) increased MOR expression in the mouse colon. *P<0.05, **P<0.01 and ***P<0.001, vs. ileum control; # P<0.05 vs. colon control. C: Berberine i.p. (0.5, 1, 2 and 5 mg/kg) had no effect on KOR mRNA expression in the mouse ileum and colon.