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. 2015 Nov 13;35(2):649–658. doi: 10.3892/or.2015.4419

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Copyright: © Nie et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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The effect of proanthocyanidins on autophagy and apoptosis when autophagy was inhibited. After treatment with 5 mM 3-MA, the expression of Beclin1 was decreased compared with that in control cells. After treatment with 40.7 µg/ml proanthocyanidins, the expression of Beclin1 increased significantly compared with that in control cells, ^**p<0.01. However, when the proanthocyanidins were added after treatment with 3-MA, Beclin1 expression was significantly reduced compared with that in cells treated with proanthocyanidins alone, ^ΔΔp<0.01. (A) Data are expressed as the mean ± standard deviation (n=3). After treatment with proanthocyanidins, the level of Bcl2 decreased significantly compared with that in control cells, ^**p<0.01, whereas simultaneous addition of 3-MA significantly decreased Bcl2 expression compared with that in cells treated with proanthocyanidins alone, ^ΔΔp<0.01. (B) Data are expressed as the mean ± standard deviation (n=3).