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Prolonged periods of serum starvation slightly attenuates the antiproliferative effect of digitoxin and MonoD but markedly affect paclitaxel, colchicine and hydroxyurea sensitivity. (A) effect of PX and colchicine on H460 cells growing in CM. Cells were treated with drugs in CM. (B) effect of PX, colchicine, HU, Dig and MonoD on seven-day serum-starved H460 cells. Cells were treated with drugs in SFM. PX, paclitaxel; HU, hydroxyurea; Dig, digitoxin; SFM, serum-free media.
