TABLE 1.
Treatment of moderate and severe acne vulgaris with clindamycin (clin)-BP 3.75% aqueous gel. Comparison with vehicle, intention-to-treat population
| MODERATE ACNE (N=412) | SEVERE ACNE (N=86) | |||||
|---|---|---|---|---|---|---|
| Clin-BP 3.75% gel (N=212) | Vehicle (N=200) | P-value | Clin-BP 3.75% gel (N=41) | Vehicle (N=45) | P-value | |
| Mean age (years) | 18.1 | 19.0 | 0.148 | 18.6 | 20.8 | 0.038 |
| Gender (male/female, %) | 48.6%/51.4% | 53.0%/47.0% | 0.274 | 65.9%/34.1% | 44.4%/55.6% | 0.073 |
| LESION REDUCTION AT WEEK 12 | ||||||
| Mean percent reduction in inflammatory lesions | 61.9% | 34.3% | <0.001 | 52.6% | 18.0% | <0.001 |
| Mean percent reduction in noninflammatory lesions | 52.1% | 28.3% | <0.001 | 50.5% | 24.8% | 0.001 |
| TREATMENT SUCCESS AT WEEK 12 | ||||||
| Subjects with ≥2 grade reduction in EGSS | 31.3% | 16.7% | 0.001 | 55.1% | 18.3% | 0.002 |
| Subjects clear/almost clear (subject self-assessment) | 35.7% | 19.2% | <0.001 | 30.6% | 8.3% | 0.042 |