Table 5. Factors in the mTOR pathway significantly altered after S6K1 and/or S6K2 downregulation in ZR751 cells according to expression arrays.
Gene | S6K1 siRNA | S6K2siRNA | S6K1+S6K2siRNA |
---|---|---|---|
EIF2AK2 | up | up | |
EIF4B | up | ||
EIF4E | up | ||
EIF4EBP1 | down | ||
EIF4G2 | down | down | |
EIF5A2 | up | ||
EIF5B | up | ||
EIF6 | down | ||
ERBB3 | up | ||
IGF2R | up | ||
MAPKAP1 | up | ||
MTOR | up | ||
NGDN 1 | up | ||
PIK3R3 | up | ||
PTEN | up | up | |
RICTOR | up | ||
RPS6KA3 | up | ||
RPS6KB1 | down | up | down |
RPS6KB2 | up | down | down |
RPS6KC1 | up | ||
RPTOR | up | up |
1Neurigudin, an EIF4E binding protein.