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. 2015 Dec 23;10(12):e0145013. doi: 10.1371/journal.pone.0145013

Table 5. Factors in the mTOR pathway significantly altered after S6K1 and/or S6K2 downregulation in ZR751 cells according to expression arrays.

Gene S6K1 siRNA S6K2siRNA S6K1+S6K2siRNA
EIF2AK2 up up
EIF4B up
EIF4E up
EIF4EBP1 down
EIF4G2 down down
EIF5A2 up
EIF5B up
EIF6 down
ERBB3 up
IGF2R up
MAPKAP1 up
MTOR up
NGDN 1 up
PIK3R3 up
PTEN up up
RICTOR up
RPS6KA3 up
RPS6KB1 down up down
RPS6KB2 up down down
RPS6KC1 up
RPTOR up up

1Neurigudin, an EIF4E binding protein.