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. 2015 Dec 23;10(12):e0143907. doi: 10.1371/journal.pone.0143907

Table 1. Patient baseline clinical characteristics and univariate Cox regression analysis for prediction of mortality at 6 and 24 months after CRT-implantation.

mortality at 6 months mortality at 24 months
Total cohort HR 95% CI χ2 p HR 95% CI χ2 p
Age (years) 67 (60–72) 1.25 0.58–2.66 0.34 0.55 1.07 0.69–1.67 0.10 0.74
Male 72 (78%) 2.23 0.44–11.75 0.96 0.33 1.62 0.45–5.83 0.55 0.46
Ischaemic ethiology 46 (49%) 1.29 0.34–4.82 0.15 0.69 1.97 0.82–4.71 2.35 0.12
NYHA III/IV 81 (87%) 1.19 0.15–9.57 0.02 0.86 3.22 0.43–23.99 1.30 0.25
LBBB 84 (90%) 0.45 0.09–2.18 0.96 0.32 0.42 0.15–1.16 2.78 0.09
QRS-duration (ms) 160 (150–180) 0.41 0.19–0.91 4.77 0.02 0.59 0.36–0.97 4.30 0.03
CRT-D 43 (46%) 1.47 0.39–5.48 0.33 0.56 1.27 0.55–2.95 0.32 0.56
Optimal lead position 68 (73%) 1.21 0.25–5.82 0.05 0.81 1.37 0.50–3.75 0.37 0.54
Diabetes mellitus 29 (31%) 1.09 0.27–4.39 0.01 0.89 1.92 0.83–4.64 2.35 0.12
Hypertension 48 (51%) 0.45 0.11–1.81 1.24 0.26 0.62 0.26–1.46 1.16 0.28
Atrial fibrillation 26 (27%) 1.25 0.31–5.00 0.10 0.75 1.28 0.51–3.18 0.29 0.58
BB 85 (91%) 0.15 0.03–0.62 6.89 0.009 0.49 0.14–1.67 1.27 0.25
ACEi/ARB 88 (94%) 0.24 0.05–1.19 3.01 0.08 0.56 0.13–2.44 0.58 0.44
Diuretics 76 (81%) 1.79 0.22–14.31 0.30 0.58 2.15 0.50–9.28 1.07 0.30
AA 69 (74%) 0.25 0.06–0.93 4.21 0.04 1.03 0.38–2.81 0.00 0.94

Hazard ratios refer to 1 standard deviation increase in case of continuous variables and presence versus absence in case of categorical variables. HR: hazard ratio, CI: confidence interval, χ2: wald chi square, NYHA: New York Heart Association Classification, LBBB: left bundle branch block, CRT-D: cardiac resynchronisation therapy with defibrillator, BB: beta-blocker, ACEi/ARB: angiotensin convertase inhibitor/angiotensin receptor blocker, AA: aldosterone antagonist, LVEF: left ventricular ejection fraction, LVEDV: left ventricular end-diastolic volume, LVESV: left ventricular end-systolic volume, MI: mitral insufficiency.