Table 1. Patient baseline clinical characteristics and univariate Cox regression analysis for prediction of mortality at 6 and 24 months after CRT-implantation.
mortality at 6 months | mortality at 24 months | ||||||||
---|---|---|---|---|---|---|---|---|---|
Total cohort | HR | 95% CI | χ2 | p | HR | 95% CI | χ2 | p | |
Age (years) | 67 (60–72) | 1.25 | 0.58–2.66 | 0.34 | 0.55 | 1.07 | 0.69–1.67 | 0.10 | 0.74 |
Male | 72 (78%) | 2.23 | 0.44–11.75 | 0.96 | 0.33 | 1.62 | 0.45–5.83 | 0.55 | 0.46 |
Ischaemic ethiology | 46 (49%) | 1.29 | 0.34–4.82 | 0.15 | 0.69 | 1.97 | 0.82–4.71 | 2.35 | 0.12 |
NYHA III/IV | 81 (87%) | 1.19 | 0.15–9.57 | 0.02 | 0.86 | 3.22 | 0.43–23.99 | 1.30 | 0.25 |
LBBB | 84 (90%) | 0.45 | 0.09–2.18 | 0.96 | 0.32 | 0.42 | 0.15–1.16 | 2.78 | 0.09 |
QRS-duration (ms) | 160 (150–180) | 0.41 | 0.19–0.91 | 4.77 | 0.02 | 0.59 | 0.36–0.97 | 4.30 | 0.03 |
CRT-D | 43 (46%) | 1.47 | 0.39–5.48 | 0.33 | 0.56 | 1.27 | 0.55–2.95 | 0.32 | 0.56 |
Optimal lead position | 68 (73%) | 1.21 | 0.25–5.82 | 0.05 | 0.81 | 1.37 | 0.50–3.75 | 0.37 | 0.54 |
Diabetes mellitus | 29 (31%) | 1.09 | 0.27–4.39 | 0.01 | 0.89 | 1.92 | 0.83–4.64 | 2.35 | 0.12 |
Hypertension | 48 (51%) | 0.45 | 0.11–1.81 | 1.24 | 0.26 | 0.62 | 0.26–1.46 | 1.16 | 0.28 |
Atrial fibrillation | 26 (27%) | 1.25 | 0.31–5.00 | 0.10 | 0.75 | 1.28 | 0.51–3.18 | 0.29 | 0.58 |
BB | 85 (91%) | 0.15 | 0.03–0.62 | 6.89 | 0.009 | 0.49 | 0.14–1.67 | 1.27 | 0.25 |
ACEi/ARB | 88 (94%) | 0.24 | 0.05–1.19 | 3.01 | 0.08 | 0.56 | 0.13–2.44 | 0.58 | 0.44 |
Diuretics | 76 (81%) | 1.79 | 0.22–14.31 | 0.30 | 0.58 | 2.15 | 0.50–9.28 | 1.07 | 0.30 |
AA | 69 (74%) | 0.25 | 0.06–0.93 | 4.21 | 0.04 | 1.03 | 0.38–2.81 | 0.00 | 0.94 |
Hazard ratios refer to 1 standard deviation increase in case of continuous variables and presence versus absence in case of categorical variables. HR: hazard ratio, CI: confidence interval, χ2: wald chi square, NYHA: New York Heart Association Classification, LBBB: left bundle branch block, CRT-D: cardiac resynchronisation therapy with defibrillator, BB: beta-blocker, ACEi/ARB: angiotensin convertase inhibitor/angiotensin receptor blocker, AA: aldosterone antagonist, LVEF: left ventricular ejection fraction, LVEDV: left ventricular end-diastolic volume, LVESV: left ventricular end-systolic volume, MI: mitral insufficiency.