Table 1. Specific binding partners of the Oxaborole-Resin revealed by proteomic profiling.
| GeneDB IDs | Product | Function | Ligand competition | Resin comparison |
|---|---|---|---|---|
| Log2 H/L | Log2 H/L | |||
| Tb927.9.6870* | RNA-binding protein, putative (RBSR1) | Possible pre-mRNA splicing | -5.68 | -2.98 |
| Tb927.10.3200* | U2 splicing auxiliary factor, putative (U2AF35) | pre-mRNA splicing | -5.06 | -2.53 |
| Tb927.8.3060* | cytosolic leucyl aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 | proteolysis | -4.68 | -2.70 |
| Tb927.8.4810 | prohibitin 1 (PHB1) | mitochondrial biogenesis | -3.64 | -3.57 |
| Tb927.10.2890*; Tb11.v5.0650 | enolase | glycolysis | -3.54 | -2.57 |
| enolase, putative | ||||
| Tb927.9.8720 | fructose-1,6-bisphosphatase (FBPase) | gluconeogenesis | -3.52 | -3.22 |
| Tb927.6.1570* | 2-hydroxy-3-oxopropionate reductase, putative | valine, leucine and isoleucine degradation | -3.14 | -2.77 |
| Tb927.11.11250 | cytosolic malate dehydrogenase (cMDH) | glycolysis | -2.98 | -2.26 |
| Tb927.4.2080* | C2 domain containing protein (CC2D) | flagellum biosynthesis | -2.96 | -2.29 |
| Tb927.6.4280*; Tb927.6.4300 | glyceraldehyde 3-phosphate dehydrogenase, glycosomal (GAPDH) | glycolysis | -2.90 | -2.59 |
| Tb927.11.11680* | 2-oxoglutarate dehydrogenase E2 component, putative | tricarboxylic acid cycle | -2.79 | -2.51 |
| Tb927.4.1890 | hypothetical protein, conserved | -2.55 | -2.02 | |
| Tb927.7.1310* | hypothetical protein, conserved | -2.42 | -2.21 |
*Abnormal RIT-SEQ growth phenotype in bloodstream forms at either day 3 or day 6 or both [39].