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Assessment of 1–8 as inhibitors of K-Ras PM localisation in MDCK cell
| Emaxa | IC50 (nM)b | |
|---|---|---|
| 1 | 0.75 ± 0.02 | 1.44 ± 0.03 |
| 2 | 0.67 ± 0.02 | 3.51 ± 0.16 |
| 3 | 0.72 ± 0.03 | 7.25 ± 0.14 |
| 4 | 0.72 ± 0.01 | 3.49 ± 0.08 |
| 5 | 0.73 ± 0.06 | 4.90 ± 0.64 |
| 6 | 0.76 ± 0.04 | 4.82 ± 0.70 |
| 7 | 0.68 ± 0.01 | 14.1 ± 0.24 |
| 8 | 0.73 ± 0.05 | 5.91 ± 1.62 |
Emax = Highest Manders coefficient which describe the maximum extent of K-Ras PM mislocalisation.
IC50 = Concentration needed for 50% PM mislocalisation.
