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Assessment of 1–8 for cytotoxicity and susceptibility to P-gp mediated efflux
| SW620 IC50 (μM) | SW620 Ad300 IC50 (μM) | FRa | |
|---|---|---|---|
| 1 | 14.6 ± 2.5 | 4.0 ± 1.1 | 0.27 |
| 2 | 17.0 ± 0.6 | 12.9 ± 1.3 | 0.76 |
| 3 | 19.8 ± 1.2 | 22.5 ± 3.8 | 1.1 |
| 4 | 36.0 ± 2.3 | 12.9 ± 1.0 | 0.35 |
| 5 | 7.1 ± 0.4 | 4.0 ± 0.8 | 0.56 |
| 6 | 14.4 ± 0.6 | 11.8 ± 3.1 | 0.82 |
| 7 | 5.7 ± 0.9 | 3.1 ± 0.2 | 0.54 |
| 8 | 13.6 ± 0.4 | 16.4 ± 1.5 | 1.2 |
FR = fold resistance, calculated as the ratio IC50 SW620Ad300 / IC50 SW620.
