Table 1.
Clinical and demographic characteristics of the cohort stratified by performance of oophorectomy
| Ovarian Conservation | Oophorectomy | |||||
|---|---|---|---|---|---|---|
|
| ||||||
| N | (%) | N | (%) | P-value | Multivariable Risk Ratio (95% CI) | |
| 1121 | (7.2) | 14,527 | (92.8) | |||
| Year of diagnosis | 0.91 | |||||
| 1998 | 31 | (6.9) | 417 | (93.1) | Referent | |
| 1999 | 36 | (7.5) | 443 | (92.5) | 1.08 (0.67–1.75) | |
| 2000 | 49 | (7.8) | 581 | (92.2) | 1.12 (0.71–1.76) | |
| 2001 | 54 | (6.2) | 818 | (93.8) | 0.94 (0.60–1.46) | |
| 2002 | 76 | (8.5) | 823 | (91.6) | 1.21 (0.80–1.85) | |
| 2003 | 68 | (6.6) | 967 | (93.4) | 0.98 (0.64–1.50) | |
| 2004 | 71 | (6.6) | 1,003 | (93.4) | 0.98 (0.64–1.50) | |
| 2005 | 88 | (7.6) | 1,065 | (92.4) | 1.14 (0.76–1.73) | |
| 2006 | 90 | (7.2) | 1,167 | (92.8) | 1.08 (0.72–1.64) | |
| 2007 | 94 | (7.5) | 1,163 | (92.5) | 1.13 (0.75–1.70) | |
| 2008 | 87 | (6.7) | 1,219 | (93.3) | 1.01 (0.67–1.53) | |
| 2009 | 98 | (7.3) | 1,245 | (92.7) | 1.11 (0.74–1.67) | |
| 2010 | 100 | (7.5) | 1,238 | (92.5) | 1.14 (0.76–1.71) | |
| 2011 | 90 | (6.9) | 1,215 | (93.1) | 1.05 (0.69–1.59) | |
| 2012 | 89 | (7.1) | 1,163 | (92.9) | 1.07 (0.71–1.62) | |
| Age (years) | <0.0001 | |||||
| 45–49 | 357 | (4.7) | 7,191 | (95.3) | Referent | |
| 40–44 | 314 | (7.4) | 3,941 | (92.6) | 1.52 (1.30–1.77)** | |
| 35–39 | 241 | (10.4) | 2,070 | (89.6) | 2.19 (1.85–2.58)** | |
| 30–34 | 134 | (12.1) | 972 | (87.9) | 2.54 (2.07–3.10)** | |
| <30 | 75 | (17.5) | 353 | (82.5) | 3.64 (2.82–4.69)** | |
| Race | 0.001 | |||||
| White | 914 | (6.9) | 12,312 | (93.1) | Referent | |
| Black | 112 | (10.0) | 1,013 | (90.0) | 1.36 (1.11–1.67)* | |
| Other/unknown | 95 | (7.3) | 1,202 | (92.7) | 1.01 (0.81–1.26) | |
| Insurance status | 0.85 | |||||
| Commercial | 870 | (7.2) | 11,302 | (92.9) | Referent | |
| Medicare | 53 | (6.8) | 727 | (93.2) | 0.95 (0.72–1.26) | |
| Medicaid | 89 | (7.2) | 1,150 | (92.8) | 0.89 (0.71–1.12) | |
| Uninsured | 69 | (7.0) | 920 | (93.0) | 0.87 (0.68–1.13) | |
| Other | 12 | (7.5) | 148 | (92.5) | 0.98 (0.55–1.76) | |
| Unknown | 28 | (9.1) | 280 | (90.9) | 1.23 (0.83–1.81) | |
| Comorbidity | 0.001 | |||||
| 0 | 729 | (7.6) | 8,892 | (92.4) | -- | |
| 1 | 129 | (5.6) | 2,179 | (94.4) | -- | |
| ≥2 | 17 | (4.4) | 374 | (95.7) | -- | |
| Unknown | 246 | (7.4) | 3,082 | (92.6) | -- | |
| Region | 0.0003 | |||||
| New England | 90 | (9.1) | 895 | (90.9) | Referent | |
| Middle Atlantic | 133 | (5.8) | 2,170 | (94.2) | 0.65 (0.48–0.88)* | |
| South Atlantic | 234 | (7.8) | 2,763 | (92.2) | 0.77 (0.59–1.02) | |
| East North Central | 205 | (6.3) | 3,040 | (93.7) | 0.66 (0.50–0.87)* | |
| East South Central | 67 | (6.7) | 931 | (93.3) | 0.71 (0.50–1.02) | |
| West North Central | 68 | (5.9) | 1,090 | (94.1) | 0.64 (0.45–0.91) | |
| West South Central | 102 | (8.0) | 1,181 | (92.1) | 0.80 (0.58–1.10) | |
| Mountain | 70 | (9.4) | 679 | (90.7) | 1.02 (0.72–1.45) | |
| Pacific | 152 | (7.9) | 1,778 | (92.1) | 0.79 (0.59–1.06) | |
| Metropolitan location | 0.14 | |||||
| Metropolitan | 914 | (7.3) | 11,556 | (92.7) | Referent | |
| Urban | 148 | (6.4) | 2,184 | (93.7) | 0.89 (0.74–1.06) | |
| Rural | 12 | (4.8) | 238 | (95.2) | 0.68 (0.38–1.22) | |
| Unknown | 47 | (7.9) | 549 | (92.1) | 0.97 (0.72–1.32) | |
| Hospital type | <0.0001 | |||||
| Academic | 442 | (6.3) | 6,556 | (93.7) | Referent | |
| Comprehensive community cancer program | 563 | (7.4) | 7,025 | (92.6) | 1.74 (1.40–2.17)** | |
| Community cancer program | 114 | (11.2) | 908 | (88.9) | 1.19 (1.03–1.37)* | |
| Other1 | - | - | - | - | ||
| Grade | <0.0001 | |||||
| 1 | 790 | (8.4) | 8,627 | (91.6) | Referent | |
| 2 | 205 | (4.9) | 3,955 | (95.1) | 0.61 (0.52–0.71)** | |
| 3 | 52 | (5.2) | 940 | (94.8) | 0.70 (0.53–0.93)* | |
| Unknown | 74 | (6.9) | 1,005 | (93.1) | 0.85 (0.67–1.08) | |
| Stage | 0.001 | |||||
| IA | 997 | (7.2) | 12945 | (92.8) | Referent | |
| IB | 67 | (5.7) | 1105 | (94.3) | 0.76 (0.58–0.99)* | |
| INOS | 57 | (10.7) | 477 | (89.3) | 0.65 (0.45–0.93)* | |
Due to co-linearity, we were not able to fit comorbidity and year of diagnosis in the same model.
1
Data suppressed due to small sample size within the categories.
*
P<0.05
**
P<0.0001