Table 3.
Spearman’s correlation coefficient (ρ) and p value for significant correlations between % change in pain NRS and % change in systemic mediator levels by diagnosis (DH cohort, Other Dx cohort)
| Significantly correlated in all subjects (Figs. 1, 2) | Significantly correlated in DH cohort | Significantly correlated in Other Dx cohort | |||
|---|---|---|---|---|---|
| Spearman’s coefficient (ρ) | p value | Spearman’s coefficient (ρ) | p value | ||
| GM-CSF | 0.701 | 0.035 | – | NS | |
| HGF | x | – | NS | 0.837 | 0.038 |
| IFN-α2 | x | 0.773 | 0.015 | 0.837 | 0.038 |
| IL-1β | – | NS | 0.837 | 0.038 | |
| IL-1ra | – | NS | 0.837 | 0.038 | |
| IL-2Rα | 0.748 | 0.021 | – | NS | |
| IL-6 | x | 0.731 | 0.025 | – | NS |
| IL-9 | – | NS | 0.837 | 0.038 | |
| IL-10 | x | 0.731 | 0.025 | – | NS |
| IL-12 | – | NS | 0.837 | 0.038 | |
| IL-12p40 | 0.840 | 0.005 | – | NS | |
| IL-18 | x | 0.765 | 0.016 | – | NS |
| MCP-1 | x | – | NS | 0.956 | 0.003 |
| MIG | x | – | NS | 0.956 | 0.003 |
| SCF | x | 0.782 | 0.013 | 0.837 | 0.038 |
| SCGF-β | x | 0.874 | 0.002 | – | NS |
| TRAIL | x | – | NS | 0.837 | 0.038 |
| VEGF | – | NS | 0.837 | 0.038 | |
Changes in mediators found to be correlated in all subjects, in DH, and in Other Dx are marked in italics