Table 3.

Multivariate prognostic model for second-line chemotherapy in advanced BTC [28]

Factors	PFS after first line CT ≥6 months
	Previous surgery on primary tumor
	Pretreatment CA19.9 ≤152 U
	ECOG performance status 0
Prognostic Groups
Good-risk	0–1, negative prognostic factors
Intermediate-risk	2, negative prognostic factors
Poor-risk	3–4, negative prognostic factors
Median OS (months)
Good-risk	13.1 (CI 95 % 9–17.2)
Intermediate-risk	6.6 (CI 95 % 5.2–8.0)
Poor-risk	3.7 (CI 95 % 3.0–4.4)

PFS progression-free survival, CT chemotherapy, OS overall survival