Table 1.

Selection criteria for BRCA genetic testing

Regardless of family history:

Women with synchronous or metachronous BC and OC

BC ≤35 years (or BC ≤40 years in case of uninformative familya)

Bilateral BC (the first diagnosed ≤40 years)

Triple-negative BC ≤50 years

High-grade epithelial non-mucinous OC (or fallopian tube or primary peritoneal cancer)

2 or more first degree relativesb with any combination of the following high-risk features:

Bilateral BC + another BC <50 years

Male breast cancer

BC + OC

Two cases of BC diagnosed before age 50 years

3 or more direct relativesb with BC and/or OC:

≥3 BC ± OC

BC breast cancer, OC ovarian cancer

^aLess than 2 women who have lived until age 45 or older in each side of the family

^bIn the same side of the family