Fig. 1.

Cholesterol biosynthesis pathway is altered in CEM/R2 cells. a Outlined cholesterol synthesis pathway in which all genes with increased mRNA expression are highlighted in green and HMGCR as its mRNA expression level is lower in CEM/R2 cells is highlighted in red. Major points of inhibition by cholesterol biosynthesis inhibitors are highlighted in red. b mRNA expression levels of all genes involved in the cholesterol biosynthetic pathway is shown as log2 fold over relative mRNA expression for each gene in CEM cells. Significance was assessed using a two-tailed unpaired t test. Data are shown as mean ± SEM of six independent experiments. *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001