Fig. 2. ROC curves for ROMA algorithm, CA125, and HE4 in patients with normal population and ovarian cancer. (A) ROC curves for overall patients. AUC for CA125 showed marginal superiority to AUC for HE4 (P = 0.083) and for ROMA (P = 0.066). (B) ROC curves for premenopausal patients. In premenopausal women, AUC for HE4 (P = 0.640) and for ROMA (P = 0.610) was not different from that for CA125. (C) ROC curves for postmenopausal patients. In postmenopausal women, AUC for CA125 showed marginal superiority to AUC for HE4 (P = 0.091) and for ROMA (P = 0.087).
