Table 1.

Studies already published about E6 oncoprotein.

Interaction with host cell	Virus type	Method	References
Facilitating virus entry	BPV	E6 facilitates the BPV entry by clathrin interaction	[35]
Antiapoptotic effect	HPV	E6 promotes Bax degradation, resulting in an antiapoptotic effect	[114, 115]
Binding to E6AP ubiquitin ligase	HPV	E6 expressed in E. coli and insects binds to E6AP ubiquitin ligase	[50, 95, 116, 117]
Binding to DNA	HPV	E6 expressed in E. coli binds with DNA	[118–120]
Cell immortalization	HPV	E6 promotes p53 degradation and cell immortalization	[121–123]
Epigenetic downregulation of p53	HPV	E6 expressed in baculovirus induces hypoacetylation of p53	[124, 125]
	HPV	E6 expressed in E. coli interacts with p300/CBP, reducing p53 levels	[126]
	BPV	E6 interacts with p300/CBP, reducing p53 levels	[51]
Disruption of mitotic apparatus	HPV	E6 transfected using LXSN vectors	[29, 30, 127]
Malignant transformation in cell culture	HPV	Complete genome of HPV-16 transfected in NIH 3T3 cells	[45, 88, 128–130]
Interaction with paxillin	BPV	E6 of BPV-1 interacts with paxillin, reducing the focal adhesion	[34, 69, 72, 131, 132]
Repressor activity of telomerases	HPV	E6 induces the hTERT expression, reducing the telomerase activity	[96, 133, 134]
Immune depletion	HPV	E6 expressed in yeast reduces the levels of interferon regulatory factor-3	[135]