Table 1.
Sequential treatment strategies.
| First-line TKI | Second-line TKI | Chemotherapy/stem-cell transplantation |
|---|---|---|
| Chemotherapy∗ | — | — |
| Imatinib | — | Chemotherapy/stem-cell transplantation |
| Bosutinib | — | Chemotherapy/stem-cell transplantation |
| Dasatinib | — | Chemotherapy/stem-cell transplantation |
| Nilotinib | — | Chemotherapy/stem-cell transplantation |
| Imatinib | Bosutinib | Chemotherapy/stem-cell transplantation |
| Imatinib | Dasatinib | Chemotherapy/stem-cell transplantation |
| Imatinib | Nilotinib | Chemotherapy/stem-cell transplantation |
| Imatinib | Ponatinib | Chemotherapy/stem-cell transplantation |
| Bosutinib | Dasatinib | Chemotherapy/stem-cell transplantation |
| Bosutinib | Nilotinib | Chemotherapy/stem-cell transplantation |
| Bosutinib | Ponatinib | Chemotherapy/stem-cell transplantation |
| Dasatinib | Bosutinib | Chemotherapy/stem-cell transplantation |
| Dasatinib | Nilotinib | Chemotherapy/stem-cell transplantation |
| Dasatinib | Ponatinib | Chemotherapy/stem-cell transplantation |
| Nilotinib | Bosutinib | Chemotherapy/stem-cell transplantation |
| Nilotinib | Dasatinib | Chemotherapy/stem-cell transplantation |
| Nilotinib | Ponatinib | Chemotherapy/stem-cell transplantation |
TKI: tyrosine kinase inhibitor.
∗Hydroxyurea.