Table 1.
Valrubicin’s antibacterial effect on P. acnes.
| Valrubicin concentration and formulation | 1.4.L1 | 12.1.L1 | 30.2.L1 |
|---|---|---|---|
| 250 mg/mL in acetone | * | * | * |
| 25 mg/mL in acetone/DMSO (1:10) | * | * | * |
| 5 μg/mL in acetone/sterile water (1:10,000) | * | * | * |
| 40 mg/mL (Valstar®) in cremophor/ethanol (1:1) | * | * | * |
| 10 mg/mL (Valstar®) in cremophor/ethanol/sterile water (1:1:4) | * | * | * |
| 10 mg/mL in cream (1% batch) | * | * | * |
| 10 mg/mL in cream gel (1% batch) | * | * | * |
* indicates no clearing of the bacterial layer. Vehicles alone demonstrated no antibacterial effect and penicillin, used as positive control, showed strong bacterial clearing in all three P. acnes strains.