Table 5.
Experiments in MVA85A-boosted animals vs BCG-vaccinated or naïve animals: bacterial loads, reported as log10 CFU
| Intervention | Study ID | Model | MVA85A booster |
BCG alone |
No vaccine |
Difference detected? MVA85A/BCG vs BCG | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean | SE | n | Mean | SE | n | Mean | SE | n | ||||
| BCG/MVA85A/ FP9.Ag85A | Williams 2005 (a) experiment 315 | Guinea pigs | ND | ND | 6 | ND | ND | 6 | ND | ND | 6 | No |
| Williams 2005 (a) experiment 415 | Guinea pigs | ND | ND | 6 | ND | ND | 6 | ND | ND | 6 | No | |
| BCG/MVA85A | aGoonetilleke 20031 7 | Mice | 4.5 | 0.2 | 9 to 12 | 4.6 | 0.8 | 9 to 12 | 5.5 | 0.4 | 9 to 12 | MVA85A: parenteral, no MVA85A intranasal, yes |
| bGoonetilleke 20031 7 | Mice | 3 | 0.2 | 9 to 12 | 4.6 | 0.8 | 9 to 12 | 5.5 | 0.4 | 9 to 12 | ||
| Tchilian 2008 (Berlin)14 | Mice | 3.8 | 0.09 | 5 | 3.8 | 0.1 | 4 | 4.75 | 0.18 | 5 | No | |
| Tchilian 2008 (Oxford)14 | Mice | 5.5 | 0.13 | 6 | 5.5 | 0.18 | 5 | 6.2 | 0.03 | 5 | ||
| Verrick 20091 9 | Macaques | 3.15 | 0.39 | 6 | 3.72 | 0.39 | 6 | 4.15 | 0.62 | 6 | No | |
| Vordermeier 20091 | Calves | 2.313 | 0.5 | 10 | 2.930 | 0.34 | 10 | 3.487 | 0.4 | 10 | No | |
| Sharpe 20101 3 | Macaques | 6.5 | 0.7 | 6 | 6 | 0.52 | 6 | 7.5 | 0.33 | 4 | No | |
ND, no data.
aIntranasal administration.
bParenteral administration.