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. 2015 Oct 21;6(4):1053–1075. doi: 10.3390/genes6041053

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

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Potential clinical and research applications of epigenetic analyses of CTCs. Standard blood samples or diagnostic leukapheresis products obtained from patients with cancer can be used for CTC enrichment, detection and isolation by different workflows. Isolated CTCs may be analyzed for DNA methylation by different technologies. The information collected from these analyses can be used to address basic molecular mechanisms of metastasis and, in the future, may also prove to be of value for clinical applications.