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. 2015 Oct 21;6(4):1076–1112. doi: 10.3390/genes6041076

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

TCA-cycle related epigenetic compounds: (a) overview map and profiles of histone JmjC- and DNA TET-demethylases; (b) gene expression profiles of TCA-related enzymes and (c) gene set enrichment profiles of GO-gene sets related to TCA; (d) PSF-profiles of metabolic products along the TCA-cycle. Fumarate and succinate can act as antagonists of αKG to inhibit αKG-dependent dioxygenases. Note that the PSF profiles of all metabolites are very similar and virtually are anti-correlated with the expression of the demethylases shown in part a.