Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Oct 21;6(4):1076–1112. doi: 10.3390/genes6041076

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2015 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

(a) The expression profiles of the methyltransferases and demethylases of H3K9, H3K4, H3K27 and of DNA-CpG’s suggest a shift of expression of the affected genes towards repressed and CpG-methylated promoter states. The scheme is redrawn from Figure 4 and supplemented by selected expression profiles of the respective enzymes determined from the lymphoma cohort studied. The triangles indicate the shift of the methylation-demethylation reactions in lymphoma compared with B cells deduced from the expression profiles from the respective enzymes. (b) Expression profiles of MYC and of the mean total expression averaged over all SOM-metagenes of each samples. Total expression is consistently activated in lymphoma except MM compared with B and GCB cells, whereas MYC is on high level in BL and IntL carrying genetic activating MYC defects.