Study | Gender of Participants | Vitamin D Supplement | Sub Group | Dose (IU) | Follow Up in Weeks | Number of Participants | Mean 25(OH)D in nmol/L | SD in nmol/L |
---|---|---|---|---|---|---|---|---|
Ala-Houhala, M., et al., 1988 [17] | Both | None | 0 | 52 | 27 | 43.3 | 19.5 | |
Not specified | 400 | 52 | 24 | 71.3 | 23.8 | |||
Aloia, J., et al., 2010 [18] | Both | D3 | 4000 | 13 | 35 | 111.7 | 30.0 | |
Aloia, J.F., et al., 2005 [19] | Female | D3 | 800 | 13 | 104 | 70.8 | 22.9 | |
Biancuzzo, R.M., et al., 2010 [20] | Both | None | 0 | 11 | 17 | 45.3 | 16.0 | |
D3 | In orange juice | 1000 | 11 | 16 | 76.8 | 21.3 | ||
In capsules | 1000 | 11 | 18 | 70.0 | 27.5 | |||
D2 | In orange juice | 1000 | 11 | 20 | 66.0 | 18.5 | ||
In capsules | 1000 | 11 | 15 | 68.5 | 26.3 | |||
Bolton-Smith, C., et al., 2007 [21] | Female | None | 0 | 52 | 55 | 47.8 | 17.3 | |
104 | 55 | 48.8 | 13.3 | |||||
D3 | Vit D + Calcium | 400 | 52 | 55 | 74.3 | 15.3 | ||
104 | 55 | 74.5 | 15.0 | |||||
Vit D + Vit K + Calcium | 400 | 52 | 58 | 73.0 | 16.3 | |||
104 | 58 | 70.8 | 16.5 | |||||
Cashman, K.D., et al., 2012 [22] | Both | None | 0 | 5 | 13 | 39.7 | 11.1 | |
10 | 13 | 41.2 | 11.1 | |||||
D3 | 800 | 5 | 16 | 64.1 | 9.5 | |||
10 | 16 | 69.0 | 8.7 | |||||
Dawson-Hughes, B., et al., 1991 [23] | Female | None | 0 | 48 | 121 | 60.6 | 28.5 | |
D3 | 400 | 48 | 125 | 92.1 | 23.6 | |||
Dawson-Hughes, B., et al., 1995 [24] | Female | Not specified | 100 | 39 | 124 | 66.3 | 25.5 | |
700 | 39 | 123 | 100.1 | 24.5 | ||||
Diamond, T., et al., 2013 [25] | Both | D3 | 2000 | 12 | 11 | 75.3 | 15.9 | |
5000 | 12 | 15 | 114.4 | 22.2 | ||||
Gallagher, J.C., et al., 2014 [26] | Both | D3 | African American women | 2400 | 52 | 20 | 97.8 | 16.5 |
White women | 2400 | 52 | 5 | 108.0 | 14.3 | |||
Harris, S.S., et al., 2012 [27] | Both | None | 0 | 12 | 43 | 37.4 | 16.1 | |
D3 | 4000 | 12 | 46 | 81.1 | 27.9 | |||
Holick, M.F., et al., 2008 [28] | Both | None | 0 | 11 | 16 | 47.0 | 19.8 | |
D3 | 1000 | 11 | 20 | 72.3 | 27.5 | |||
D2 | 1000 | 11 | 18 | 67.0 | 24.0 | |||
D3+D2 | 1000 | 11 | 14 | 71.0 | 19.3 | |||
Jensen, C., et al., 2002 [29] | Female | Not specified | 400 | 52 | 22 | 50.3 | 19.1 | |
104 | 22 | 80.4 | 21.6 | |||||
156 | 22 | 76.6 | 22.1 | |||||
Karkkainen, M.K., et al., 2010 [30] | Female | D3 | 0 | 156 | 287 | 55.9 | 21.8 | |
800 | 156 | 306 | 74.6 | 21.9 | ||||
Kilpinen-Loisa, P., et al., 2009 [31] | Both | D3 | 800 | 26 | 72 | 82.0 | 21.0 | |
Kyriakidou-Himonas, M., et al., 1999 [32] | Female | D3 | 800 | 12 | 10 | 63.3 | 11.1 | |
Lagunova, Z., et al., 2013 [33] | Both | D3 | 2000 | 4 | 11 | 78.9 | 15.3 | |
Lappe, J.M., et al., 2007 [34] | Female | None | 0 | 52 | 446 | 71.1 | 19.8 | |
D3 | 1100 | 52 | 288 | 96.0 | 21.4 | |||
Li-Ng, M., et al., 2009 [35] | Male | D3 | 2000 | 12 | 78 | 88.5 | 23.2 | |
Logan, V.F., et al., 2013 [36] | Both | None | 0 | 4 | 13 | 71.0 | 15.3 | |
8 | 13 | 61.0 | 15.3 | |||||
13 | 13 | 44.0 | 15.3 | |||||
25 | 13 | 37.0 | 17.9 | |||||
D3 | 1000 | 4 | 23 | 83.0 | 12.2 | |||
8 | 23 | 83.0 | 14.7 | |||||
13 | 23 | 80.0 | 17.1 | |||||
25 | 23 | 80.0 | 19.6 | |||||
D2 | 1000 | 4 | 25 | 70.0 | 12.9 | |||
8 | 25 | 66.0 | 12.9 | |||||
13 | 25 | 62.0 | 14.7 | |||||
25 | 25 | 56.0 | 11.0 | |||||
Molgaard, C., et al., 2010 [37] | Female | None | 0 | 26 | 73 | 47.0 | 20.0 | |
52 | 73 | 39.7 | 17.7 | |||||
D3 | 200 | 26 | 74 | 54.5 | 12.0 | |||
52 | 74 | 52.9 | 16.3 | |||||
400 | 26 | 73 | 59.4 | 13.2 | ||||
52 | 74 | 57.9 | 14.3 | |||||
Nelson, M.L., et al., 2009 [38] | Female | None | 0 | 52 | 31 | 72.7 | 27.8 | |
D3 | 800 | 52 | 31 | 97.4 | 31.3 | |||
Oosterwerff, M.M., et al., 2014 [39] | Both | None | 0 | 8 | 53 | 24.0 | 16.0 | |
16 | 53 | 23.0 | 15.0 | |||||
D3 | 1200 | 8 | 57 | 58.0 | 12.0 | |||
16 | 57 | 60.0 | 16.0 | |||||
Orwoll, E.S., et al., 1988 [41] | Male | None | 0 | 26 | 46 | 55.0 | 15.0 | |
52 | 46 | 60.0 | 18.0 | |||||
D3 | 1000 | 26 | 46 | 75.0 | 18.0 | |||
52 | 46 | 85.0 | 20.0 | |||||
Orwoll, E.S., et al., 1989 [40] | Both | None | 0 | 104 | 14 | 45.0 | 22.5 | |
D3 | 1600 | 52 | 14 | 240.0 | 97.5 | |||
104 | 17 | 225.0 | 87.5 | |||||
Pignotti, G.A., et al., 2010 [42] | Female | None | 0 | 13 | 29 | 58.8 | 24.7 | |
D3 | 400 | 13 | 29 | 59.5 | 17.5 | |||
Putman, M.S., et al., 2013 [43] | Both | D3 | 200 | 11 | 25 | 28.9 | 7.0 | |
1000 | 11 | 29 | 30.1 | 6.6 | ||||
Rajakumar, K., et al., 2008 [44] | Both | D3 | Non-obese | 400 | 4 | 18 | 72.8 | 16.8 |
Obese | 400 | 4 | 21 | 65.5 | 20.3 | |||
Schaafsma, A., et al., 2000 [45] | Female | D3 | 400 | 13 | 46 | 108.0 | 25.0 | |
26 | 46 | 111.0 | 23.0 | |||||
52 | 46 | 121.0 | 27.0 | |||||
Schnatz, P.F., et al., 2014 [46] | Female | None | 0 | 104 | 291 | 45.5 | 23.7 | |
D3 | 400 | 104 | 285 | 60.8 | 30.5 | |||
Schou, A.J., et al., 2003 [47] | Both | None | Placebo then supplementation | 0 | 4 | 10 | 33.7 | 10.4 |
Supplementation then placebo | 0 | 4 | 10 | 32.3 | 13.0 | |||
D3 | Placebo then supplementation | 600 | 4 | 10 | 50.2 | 14.2 | ||
Supplementation then placebo | 600 | 4 | 10 | 43.4 | 9.2 | |||
Smith, S.M., et al., 2009 [48] | Both | None | 0 | 18 | 18 | 38.0 | 17.0 | |
25 | 18 | 34.0 | 12.0 | |||||
D3 | 400 | 18 | 19 | 55.0 | 19.0 | |||
25 | 19 | 57.0 | 15.0 | |||||
1000 | 18 | 18 | 63.0 | 20.0 | ||||
25 | 18 | 63.0 | 25.0 | |||||
2000 | 18 | 7 | 71.0 | 20.0 | ||||
25 | 7 | 71.0 | 23.0 | |||||
Van Der Klis, F.R., et al., 1996 [49] | Female | None | 0 | 5 | 41 | 58.5 | 10.7 | |
D3 | 400 | 5 | 19 | 87.9 | 28.1 | |||
800 | 5 | 19 | 87.9 | 28.1 | ||||
19 | 102.6 | 28.8 | ||||||
Vieth, R., et al., 2001 [50] | Both | D3 | 1000 | 12 | 33 | 68.7 | 16.9 | |
4000 | 12 | 28 | 96.4 | 14.6 | ||||
Wamberg, L., et al., 2013 [51] | Both | None | 0 | 26 | 26 | 46.8 | 21.2 | |
D3 | 7000 | 26 | 26 | 110.0 | 17.3 | |||
Zwart, S.R., et al., 2011 [52] | Both | Not specified | 2000 | 13 | 15 | 73.0 | 17.0 | |
26 | 15 | 79.0 | 16.0 |
Footnote: SD: Standard Deviation: Reported SD ranged from 6.6 to 97.5, had a mean value of 19.9 and a median value of 17.8 nmol/L.