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. 2015 Dec 4;7(12):10189–10208. doi: 10.3390/nu7125527
Study Gender of Participants Vitamin D Supplement Sub Group Dose (IU) Follow Up in Weeks Number of Participants Mean 25(OH)D in nmol/L SD in nmol/L
Ala-Houhala, M., et al., 1988 [17] Both None 0 52 27 43.3 19.5
Not specified 400 52 24 71.3 23.8
Aloia, J., et al., 2010 [18] Both D3 4000 13 35 111.7 30.0
Aloia, J.F., et al., 2005 [19] Female D3 800 13 104 70.8 22.9
Biancuzzo, R.M., et al., 2010 [20] Both None 0 11 17 45.3 16.0
D3 In orange juice 1000 11 16 76.8 21.3
In capsules 1000 11 18 70.0 27.5
D2 In orange juice 1000 11 20 66.0 18.5
In capsules 1000 11 15 68.5 26.3
Bolton-Smith, C., et al., 2007 [21] Female None 0 52 55 47.8 17.3
104 55 48.8 13.3
D3 Vit D + Calcium 400 52 55 74.3 15.3
104 55 74.5 15.0
Vit D + Vit K + Calcium 400 52 58 73.0 16.3
104 58 70.8 16.5
Cashman, K.D., et al., 2012 [22] Both None 0 5 13 39.7 11.1
10 13 41.2 11.1
D3 800 5 16 64.1 9.5
10 16 69.0 8.7
Dawson-Hughes, B., et al., 1991 [23] Female None 0 48 121 60.6 28.5
D3 400 48 125 92.1 23.6
Dawson-Hughes, B., et al., 1995 [24] Female Not specified 100 39 124 66.3 25.5
700 39 123 100.1 24.5
Diamond, T., et al., 2013 [25] Both D3 2000 12 11 75.3 15.9
5000 12 15 114.4 22.2
Gallagher, J.C., et al., 2014 [26] Both D3 African American women 2400 52 20 97.8 16.5
White women 2400 52 5 108.0 14.3
Harris, S.S., et al., 2012 [27] Both None 0 12 43 37.4 16.1
D3 4000 12 46 81.1 27.9
Holick, M.F., et al., 2008 [28] Both None 0 11 16 47.0 19.8
D3 1000 11 20 72.3 27.5
D2 1000 11 18 67.0 24.0
D3+D2 1000 11 14 71.0 19.3
Jensen, C., et al., 2002 [29] Female Not specified 400 52 22 50.3 19.1
104 22 80.4 21.6
156 22 76.6 22.1
Karkkainen, M.K., et al., 2010 [30] Female D3 0 156 287 55.9 21.8
800 156 306 74.6 21.9
Kilpinen-Loisa, P., et al., 2009 [31] Both D3 800 26 72 82.0 21.0
Kyriakidou-Himonas, M., et al., 1999 [32] Female D3 800 12 10 63.3 11.1
Lagunova, Z., et al., 2013 [33] Both D3 2000 4 11 78.9 15.3
Lappe, J.M., et al., 2007 [34] Female None 0 52 446 71.1 19.8
D3 1100 52 288 96.0 21.4
Li-Ng, M., et al., 2009 [35] Male D3 2000 12 78 88.5 23.2
Logan, V.F., et al., 2013 [36] Both None 0 4 13 71.0 15.3
8 13 61.0 15.3
13 13 44.0 15.3
25 13 37.0 17.9
D3 1000 4 23 83.0 12.2
8 23 83.0 14.7
13 23 80.0 17.1
25 23 80.0 19.6
D2 1000 4 25 70.0 12.9
8 25 66.0 12.9
13 25 62.0 14.7
25 25 56.0 11.0
Molgaard, C., et al., 2010 [37] Female None 0 26 73 47.0 20.0
52 73 39.7 17.7
D3 200 26 74 54.5 12.0
52 74 52.9 16.3
400 26 73 59.4 13.2
52 74 57.9 14.3
Nelson, M.L., et al., 2009 [38] Female None 0 52 31 72.7 27.8
D3 800 52 31 97.4 31.3
Oosterwerff, M.M., et al., 2014 [39] Both None 0 8 53 24.0 16.0
16 53 23.0 15.0
D3 1200 8 57 58.0 12.0
16 57 60.0 16.0
Orwoll, E.S., et al., 1988 [41] Male None 0 26 46 55.0 15.0
52 46 60.0 18.0
D3 1000 26 46 75.0 18.0
52 46 85.0 20.0
Orwoll, E.S., et al., 1989 [40] Both None 0 104 14 45.0 22.5
D3 1600 52 14 240.0 97.5
104 17 225.0 87.5
Pignotti, G.A., et al., 2010 [42] Female None 0 13 29 58.8 24.7
D3 400 13 29 59.5 17.5
Putman, M.S., et al., 2013 [43] Both D3 200 11 25 28.9 7.0
1000 11 29 30.1 6.6
Rajakumar, K., et al., 2008 [44] Both D3 Non-obese 400 4 18 72.8 16.8
Obese 400 4 21 65.5 20.3
Schaafsma, A., et al., 2000 [45] Female D3 400 13 46 108.0 25.0
26 46 111.0 23.0
52 46 121.0 27.0
Schnatz, P.F., et al., 2014 [46] Female None 0 104 291 45.5 23.7
D3 400 104 285 60.8 30.5
Schou, A.J., et al., 2003 [47] Both None Placebo then supplementation 0 4 10 33.7 10.4
Supplementation then placebo 0 4 10 32.3 13.0
D3 Placebo then supplementation 600 4 10 50.2 14.2
Supplementation then placebo 600 4 10 43.4 9.2
Smith, S.M., et al., 2009 [48] Both None 0 18 18 38.0 17.0
25 18 34.0 12.0
D3 400 18 19 55.0 19.0
25 19 57.0 15.0
1000 18 18 63.0 20.0
25 18 63.0 25.0
2000 18 7 71.0 20.0
25 7 71.0 23.0
Van Der Klis, F.R., et al., 1996 [49] Female None 0 5 41 58.5 10.7
D3 400 5 19 87.9 28.1
800 5 19 87.9 28.1
19 102.6 28.8
Vieth, R., et al., 2001 [50] Both D3 1000 12 33 68.7 16.9
4000 12 28 96.4 14.6
Wamberg, L., et al., 2013 [51] Both None 0 26 26 46.8 21.2
D3 7000 26 26 110.0 17.3
Zwart, S.R., et al., 2011 [52] Both Not specified 2000 13 15 73.0 17.0
26 15 79.0 16.0

Footnote: SD: Standard Deviation: Reported SD ranged from 6.6 to 97.5, had a mean value of 19.9 and a median value of 17.8 nmol/L.