Figure 3.

The response of urinary (n = 42) and serum (n = 38) magnesium during flight, expressed as the area under the curve (AUC), is related to the change in total body bone mineral content (BMC) after flight on the International Space Station (upper panels), and the AUC of urinary and serum Mg after 28 to 90 days of bed rest (n = 27 urine and serum) is related to the change in total body BMC after 60 to 90 days of bed rest (lower panels). Each circle represents an individual crewmember. In the upper panels, filled circles represent crewmembers who had access to the Advanced Resistive Exercise Device (ARED) and open circles represent crewmembers who had access to the interim resistive exercise device (iRED). Crewmembers treated with the bisphosphonate alendronate are shown with gray triangles. Pearson correlation coefficients are presented for significant correlations.