Table 3.
Relative quantification of electron microscopy examination of rat hepatocytes.
| Treatment Group | Nuclear Clumping and Fragmentation (% of Control) | Damaged Nuclear Membrane (% of Control) | Phagolysosomes (as a Fraction of the Control) | Apoptotic Bodies (as a Fraction of the Control) |
|---|---|---|---|---|
| AZT only | +++ | + | ++ | + |
| AZT + NAR | ++ | - | + | + |
| AZT + VITE | ++ | - | + | + |
| d4T only | +++ | ++ | +++ | ++ |
| d4T + NAR | ++ | - | + | + |
| d4T + VITE | ++ | - | + | + |
| CONTROL | - | - | - | - |
+++ ≥ 50%, ++ = 20% to 50% and + ≤ 20% relative to control rats. Values recorded are an average of the values obtained by observation of at least five fields from the same sample by two independent examiners who were blinded to the experiment carried out.