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. 2015 Dec 12;7(12):5417–5434. doi: 10.3390/toxins7124891

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Serial mean effects (± SEMs) of 24 h infusions (shaded areas) of low (LD50) or high (LD100) doses of lethal toxin (LT) compared to protective antigen alone (controls) on changes from baseline in mean arterial pressure (MAP, panel A), heart rate (HR, panel B), central venous pressure (CVP, panel C), cardiac index (CI, panel D) and left ventricular ejection fraction (LVEF, panel E). The p-values shown are for the effects of LT compared to control. Increases or decreases with LT (compared to controls) are indicated by symbols above or below the dashed horizontal no-effect line respectively.