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. 2015 Sep 23;2015(32):6965–6982. doi: 10.1002/ejoc.201500852

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© 2015 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

© 2015 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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An ω-transaminase variant produced by directed evolution enabled the stereoselective amination of a bulky-bulky ketone for the production of sitagliptin (2), a drug used in the treatment of type II diabetes.